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研究组在美国科学院院刊发表题为“Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity”的文章
作者: 文章来源: 点击数: 更新时间:2012-09-27
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2012 Jul 24;109(30):12248-53. doi: 10.1073/pnas.1202835109. Epub 2012 Jul 9.

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity.

Source

Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

Abstract

Depression is a debilitating mental illness and is often comorbid with metabolic disorders such as type 2 diabetes. Adiponectin is an adipocyte-derived hormone with antidiabetic and insulin-sensitizing properties. Here we show that adiponectin levels in plasma are reduced in a chronic social-defeat stress model of depression, which correlates with decreased social interaction time. A reduction in adiponectin levels caused by haploinsufficiency results in increased susceptibility to social aversion, "anhedonia," and learned helplessness and causes impaired glucocorticoid-mediated negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis. Intracerebroventricular (i.c.v.) injection of an adiponectin neutralizing antibody precipitates stress-induced depressive-like behavior. Conversely, i.c.v. administration of exogenous adiponectin produces antidepressant-like behavioral effects in normal-weight mice and in diet-induced obese diabetic mice. Taken together, these results suggest a critical role of adiponectin in depressive-like behaviors and point to a potential innovative therapeutic approach for depressive disorders.

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Link: http://www.pnas.org/content/109/30/12248.long

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